EPI is one of the conditions which can contribute to the malabsorption syndrome.
In dogs and cats the result is inadequate concentrations of all the pancreatic enzymes and of bicarbonate in the intestine lumen.
EPI can be subclinical for many months or even years
H2 - receptor inhibitors (e.g. cimetidine) are useful because they reduce gastric acid secretion, and so less pancreatic enzyme is denatured during passage through the stomach.
If bacterial overgrowth is present oral antibiotics (e.g. neobiotic) may be indicated.
With enzyme replacement and cimetidine (300mg), or (if appropriate) 300mg neomycin, faecal fat concentrations can be returned to normal.(Strombeck and Guilford - Small Animal Gastroenterology 2e Wolfe) Other authors recommend different doses eg 300mg cimetidine / 20 kg body weight (Murdoch DB in Canine Medicine and Therapeutics - Blackwell Scientific Publications 3e 1991)
The following dietary management is recommended: