Although this is a sensitive test it is difficult to perform in dogs and therefore not widely used in general practice.
Method for urine collection technique
0.25ml (16.7mg)/Kg body weight of the patient of BT-PABA is given by stomach tube to a patient that has been starved for 18 hours, followed by 25-100ml water. After 6 hours confinement urine is collected by catheterization of the bladder and analysed for PABA.
A similar test can be used and plasma concentrations are measured. Peak plasma concentrations of PABA are greater than 350 µg/dl in normal dogs.
Normal dogs excrete over 70% of the PABA administered orally in the urine within 6 hours.
In dogs with exocrine pancreatic insufficiency peak plasma concentrations are less than 150µg/dl and less than 15% of orally administered PABA is excreted in the urine in a six hour period.
Last updated : October 2013