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This information is provided by
Provet for educational purposes only.
You should seek the advice of your
veterinarian if your pet is ill as only he or she can correctly advise on the
diagnosis and recommend the treatment that is most appropriate for your pet.
Zinc is an
important mineral which is involved in many biochemical pathways - some of
which explain its important role in the maintenance of healthy skin Zinc
is an important component of several metalloenzymes in the body. Deficiency of
zinc leads to several
clinical signs :
- Dermatitis
- Thinning of the hair coat - alopecia due to hair loss
- Slow rate of hair growth
- Dullness of the hair coat
- Increased scurf formation
- The coat appears to be rough, staring and unkempt
- Ulceration of the skin
- Thick crusty parakeratotic hyperkeratotic skin lesions
- Acanthosis
Non-specific signs may include :
- Anorexia
- Depression
- Fever
- Lymphadenopathy
- Poor growth rate
These lesions affect several sites :
- Axilla
- Ear canals
- Distal extremities including the footpads - also have paronechia,
fissures and cracks
- Groin
- Mucocutaneous junctions
- Over joints
- Tail
Several recognised clinical syndromes have been shown to be responsive to
zinc therapy including :
- Juvenile hyperkeratosis (also called dry juvenile pyoderma) - thought to
have been due to zinc deficiency in the diet
- Siberian Husky and Alaskan Malamute syndrome - lesions develop in early
adulthood
- Bull Terrier acrodermatitis - due to abnormal zinc absorption and
metabolism
- German Shepherd dogs have been reported to develop the disease in
rapidly-growing individuals fed zinc-deficient diets
The biochemical roles of zinc that explain these changes include :
- Zinc is an important component of metalloenzymes (eg carbonic anhydrase)
- Zinc is important for cell replication and differentiation
- Zinc has an important role in protein synthesis, nucleic acid synthesis
and carbohydrate metabolism
- Zinc is important for normal essential fatty acid (EFA) metabolism - and
EFAs are very important in maintaining normal skin health.
- Zinc has an important role to play in the production , storage and
secretion of hormones including adrenal corticosteroids insulin, and
testosterone
- Zinc is important for normal hormone receptor response
- Parakeratosis is due to delayed nuclear degeneration
- Zinc deficiency affects nucleic acid and collagen synthesis leading to
fissures in pads, and loss of hair
Copper deficiency is not common. It occurs most often in young puppies or
kittens due to one of 3 scenarios :
- Poor nutrition with inadequate copper in the food - most likely to occur
on a home-made or "fad" diet
- Poor bioavailability of copper in food
- Competition from other minerals in the diet (eg zinc) which reduce the
bioavailability of the copper.
Treatment is to feed a complete and balanced ration and avoid excess
mineral supplementation.
Updated October 2013
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