First broadcast on  

This information is provided by Provet for educational purposes only.

You should seek the advice of your veterinarian if your pet is ill as only he or she can correctly advise on the diagnosis and recommend the treatment that is most appropriate for your pet.

Ticarcillin-clavulanic acid combination drugs are anti-pseudomonal drugs with extended spectrum of activity


Ticarcillin is an antipseudomonal penicillin which  is effective against the following gram-negative organisms :
Enteric Rods : E.coli ; Proteus ; Salmonella

Other Gram negatives : Haemophilus ;  Pseudomonas

When combined with clavulanic acid extends the antimicrobial activity of these antibiotics to include penicillinase-producing organisms.
The ticarcillin-clavulanic acid combination must be given by intravenous or intramuscular injection.
The drug is excreted via the kidneys.
Dose rates published for use in cats and dogs in the UK are :
15-25 mg/kg 3 times daily by intravenous infusion.
Contraindications and side-effects are as for Benzylpenicillin (Penicillin G) and include :
1. Do not give to patients known to be allergic to penicillins
2. Do not give to hamsters, gerbils, guinea pigs or rabbits
3. Do not give by the intrathecal route.
4. People allergic to penicillins should not handle penicillins
Possible side-effects include :
1. Diarrhoea
2. Platelet dysfunction - reduced aggregation (ticarcillin)
3. Nephritis
4. Hypersensitivity


Updated October 2013