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This information is provided by Provet for educational purposes only.

You should seek the advice of your veterinarian if your pet is ill as only he or she can correctly advise on the diagnosis and recommend the treatment that is most appropriate for your pet.

Phenylbutazone is a less commonly prescribed drug in veterinary practice but there are some circumstances when it should not be prescribed

Toxic side-effects to phenylbutazone are likely to occur if the recommended dose rate or maximum duration of therapy is exceeded

Phenylbutazone should not be administered to :

  • Animals with clinical or subclinical :
    • Blood disorders
    • Cardiac disease*
    • Dehydration*
    • Hypotension*
    • Hypovolemia*
    • Kidney disease*
    • Liver disease*
    • Gastrointestinal inflammation - ulcers or bleeding
  • Anorectic animals
  • Animals being treated with NSAIDs or other potentially nephrotoxic drugs
  • Animals with phenylbutazone sensitivity

Phenylbutazone should be avoided, or used with great care and at a reduced dose rate in :

  • Animals under 6 weeks of age
  • Old animals - which should be screened for subclinical disease* prior to use of this drug.

Concurrent use of certain drugs should be avoided for up to 24 hours after the administration of phenylbutazone, including :

  • Other NSAIDs
  • Aminoglycoside antimicrobial drugs
  • Methoxyfluorane anesthesia
  • ACE inhibitors and other vasodilators
  • Diuretics - at high doses


Updated January 2016