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Nervous
regulation of cardiac function during aging
V G Shevchuk Abstract
broadcast on www.provet.co.uk
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Abstract
The hemodynamic changes and myocardium contractile capacity following the
extracardiac nerves stimulation with acetylcholine, norepinephrine, inderal,
regitin and atropine, as well as the activity of main enzymes of cholinergic
and adrenergic metabolism, were studied in albino rats, rabbits, and cats of
various age. With ageing, the thresholds of vagal and sympathetic nerves
influences on the heart increased, the sensitivity of heart to acetylcholine
and norepinephrine changed. In old animals, smaller atropine and inderal doses
blocked the respective cholinergic and beta-adrenergic reactions. Alterations
of transmitters metabolism play an important role in the mechanism of
age-induced changes in nervous control of cardiac function.
Reference
FIZIOLOGICHESKII ZHURNAL SSSR IMENI IM SECHENOVA = THE JOURNAL OF ,
63(8):1134-1143 1977
Updated January 2016
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