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Contractile
function and Ca2+ transport system of myocardium in ageing
R A Frolkis, L S Mkhitarian, V G Shevchuk, V E Fraifeld, L G
Vakulenko, I Syrova
Abstract
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Abstract
Experiments with animals with various species-specific life span (rats,
rabbits, cats, dogs) and different models (in situ heart, isolated perfused
heart, isolated papillary muscle) have proved the reduction of functional
capacity of the ageing heart. Diversely directional age-dependent shifts have
been established involving myocardial Ca2+ transport system, i.e. an increase
in the rate of Na+-Ca2+ exchange and passive Ca2+ transport across sarcolemma
and a decrease in its Ca2+-binding capacity and a decrease in Ca2+
accumulation by sarcoplasmic reticulum and mitochondria (Ca2+ uptake). The
experiments revealed a decrease in the Ca2+ ATPase myosin activity in the
myocardium of aged animals and absence of age changes in the K+ ATPase
activity. The findings obtained suggest that the development in the cardiac
contractile function disorders in ageing largely depends on the age-related
changes in the Ca2+ transport system.
Reference
GERONTOLOGY - INTERNATIONAL JOURNAL OF EXPERIMENTAL, CLINICAL, AND BEHAVIORAL
GERONTOLOGY , 34(1-2):64-74
1988
Updated January 2016
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