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Do
antioxidant strategies work against aging and age-associated disorders?
Propargylamines: A possible antioxidant strategy
Maruyama,W, Carrillo,MC, Kitani,K, Minami,C, Ivy,G,O, Yamamoto,T,
Kanai,S Abstract
broadcast on www.provet.co.uk
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Abstract
The free radical theory of aging was initially proposed by Harman half a
century ago primarily to explain biological aging processes. Although
administration of so-called antioxidant chemicals, which have been tested in
the past for several decades, turned out to be mostly ineffective in
prolonging the life spans of animals, the same theory of age-associated
diseases appears to be increasingly supported in the last two decades. Despite
these difficulties, the success in extending life span of 4 different animal
species (mice, rats, hamsters, and dogs) with deprenyl (including a study of
our group) indicates that there might exist another type of antioxidant
strategy in addition to a simple administration of antioxidant chemicals .
Deprenyl has also been shown to increase superoxide dismutase (SOD) and
catalase (CAT) activities selectively in brain dopaminergic tissues.
Interestingly, we have recently shown that another propargylamine, rasagiline
not only increases antioxidant enzyme activities (CAT and SOD) in brain
dopaminergic regions as deprenyl does, but also increases CAT and SOD
activities in extra-brain catecholaminergic systems such as the heart and
kidneys as well. These recent observations coupled with previous observations
on the life span of animals with deprenyl suggest that pharmacological
modulation of endogenous antioxidant enzyme activities could be one potential
antioxidant strategy against aging and age-associated disorders. If the causal
relationship between the two effects of deprenyl exists as we hypothesized, we
might be able to advance the elucidation of mechanism(s) of aging based on the
free radical theory of aging.
Reference
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES ,
928(2001):248-260 2001
Updated January 2016
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