Domestic Shorthair
The following diseases are reported to occur more frequently in the Domestic Shorthair than in the general cat population. In some cases the disease either has, or is believed to have, a genetic, hereditary cause but many of the diseases listed here do not have a proven genetic basis. 

If you do not find the disease that you are looking for in this list the disorder has probably not been reported to occur more frequently in this breed than in the cat population as a whole. Try to find it through the search button.

Alimentary tract diseases
This section includes diseases that involve the mouth, oesophagus (gullet), stomach, small intestine (duodenum and ileum), large intestine (colon and rectum), liver and pancreas.


Diseases involving the mouth

Diseases affecting the gullet (oesophagus)

Diseases involving the pancreas

Diseases affecting the small intestine

Diseases affecting the large intestine

Blood diseases

  • Haemophilia A
  • Methaemoglobin reductase deficiency (autosomal recessive)
  • Pelger-Huet anomaly (autosomal dominant)
  • Pyruvate kinase deficiency (autosomal recessive)


  • Sebaceous gland tumours

Cardiovascular diseases

Heart valve disorders

Abnormal development of major blood vessels to the heart

Heart muscle disease

Endocrine Diseases

Eye diseases

Diseases of the cornea

  • Corneal dermoid
Diseases of the eyeball
  • Coloboma - various sites
  • Lysosomal storage diseases (see Nervous diseases)
  • Microphakia

Diseases of the eyelids

Diseases of the third eyelid (nictitating membrane)

Diseases of the lens

Diseases of the retina

Hormonal diseases

Immune system diseases

Kidney and Urinary tract diseases

  • Hyperoxaluria

Liver diseases

  • Portosystemic shunts (congenital)

Nervous system diseases

  • Lysosomal storage disease- alpha mannosidosis
  • Lysosomal storage disease- GM1 gangliosidosis
  • Lysosomal storage disease - globoid cell leukodystrophy
  • Lysosomal storage disease - mucopolysaccharidosis
  • Lysosomal storage disease - sphingomyelinosis
  • Myasthenia gravis (congenital)
  • Neuroaxonal dystrophy

Orthopaedic disease

  • Mucopolysaccharidosis
  • Myasthenia gravis (congenital)

Respiratory diseases

Skin diseases

  • Ehler-Danlos syndrome
  • Lentigo simplex
  • Psychogenic alopecia
  • Skin tumours
  • Solar dermatitis (blue-eyed, white cats)


  • Porphyria (hereditary) 


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