Non-persistent, natural, contact insecticides, extracted from plants (e.g. pyrethrum). (Chrysanthemum cineranaefolium, C. roseum, C. cerneum). Also used as therapeutic agents against external insects and parasites.


[affected.gif] Animals most affected
Fish, dogs, (cattle).


[etiology.gif] Etiology
Extensive pollution as a result of poor treatment methods, careless application or following aquatic larvicidal treatment (fish). Ingestion of the agricultural product (dogs).


[toxic.gif] Toxicity
Photosensitive, photolabile products which are unstable compounds. Highly toxic to fish. Of low toxicity to birds and mammals as the active compound is rapidly degraded in the stomach to non-toxic components.

Oral doses in mg/kg:
LD50 rats 584-900

     


[clinical.gif] Clinical features
Relatively non-specific but neuromuscular and gastrointestinal effects predominate:

Respiratory and cardiac effects often very intense and pronounced:

Death due to respiratory failure.


[lesions.gif] Lesions
Non-specific: hepatic and renal degeneration


[treatm~1.gif] Treatment
No antidote. Symptomatic care only, promote excretion:
   

[labinv~1.gif]
Laboratory investigations

It is essential to have very fresh samples as the compounds degrade rapidly.