Orange-yellow herbicides and desiccants with a strong tendency to discolour matter with which they come into contact. Sometimes used as a fungicide.

[affected.gif] Animals most affected
Cattle, hares, rabbits and dogs.

[etiology.gif] Etiology

Note: the residue on vegetation and in soils is minimal, 24-48 hours post-application.

Compounds in this category
Dinoseb, dinoterb, dinitro-orthocresol

[toxic.gif] Toxicity
Dinitro compounds stimulate tissue respiration while simultaneously impairing adenosine triphosphate (ATP) synthesis. The main toxic action is the uncoupling of oxidative phosphorylation, converting all cellular energy in the form of heat and causing extreme hyperthermia. In addition, the gut flora in ruminants are able to further reduce the dinitro compounds to diamine metabolites which are capable of inducing methaemoglobinaemia.
Toxic doses: see individual compounds.

[clinical.gif] Clinical features
Febrile syndrome

[lesions.gif] Lesions

[treatm~1.gif] Treatment
No antidote. Symptomatic care only, may in itself prove to be hazardous to the animal:

In ruminants
(With methaemoglobinaemia):

[labinv~1.gif] Laboratory investigations

The samples should be frozen immediately as the compound degrades rapidly.