A dinitro-phenol herbicide, which used to be used extensively on grasses, as a defoliant for potatoes, as a dinitro-insecticide for dormant season treatment of fruit crops, as well as a fungicide against oidium. DNOC was banned in the UK in 1989 due to evidence of teratogenicity in related dinitro compounds.
For etiology, treatment and investigations, see Dinitrophenols .


[toxic.gif] Toxicity
Oral doses in mg/kg or concentrations in mg/l:
LD50 rats 25-40
  hens 26
  partridges 20-25
  rabbits 45
  dogs 50
  pigs 50
  goats 100
TD cattle 2-50
  sheep 20-50
LD sheep 25 for 5 days
    19 for 6 days
    12 for 49 days
LC50 (96 h)
fish  
 
0.243




[clinical.gif] Clinical features
Present within minutes or several hours following exposure to high concentrations by inhalation, percutaneous absorption or ingestion:


In cattle and ruminants
Clinical signs as above; animals particularly susceptible to methaemogiobinaemia (the blood becoming chocolate-brown in colour), intravascular haemolysis and hypoproteinaemia.



[lesions.gif] Lesions
Non-specific:



[treatm~1.gif] Treatment
No antidote. Symptomatic care only, which may in itself prove to be harmful to the animal:

In ruminants
(For methaemoglobinaemia):



[labinv~1.gif] Laboratory investigations

The samples should be frozen immediately as the compound degrades rapidly.