Rodenticide.


[affected.gif] Animals most affected
Dogs, cats.


[etiology.gif] Etiology
Accidental ingestion of cereal-based baits, containing up to 0.1% of the active compound. Possibility of ingestion of baits laid down with malicious intent (relatively uncommon).


[toxic.gif] Toxicity
Acts as an antagonist of vitamin B6.

Toxic oral doses in mg/kg:

LD50 mice 1.2
  rats 1.25
  rabbits 5.0
  guinea pigs 2.6
  poultry 10-20
  dogs 0.5-1.0
  hares 5.0


[clinical.gif] Clinical features
Generally clinical effects appear 1-3 hours post-ingestion:


The animal appears to suffer greatly, followed by:



[lesions.gif] Lesions
Non-specific:  


[treatm~1.gif] Treatment
antidotes may be of use in specific cases:

Note: if vitamin B6 is given in association with vitamin B1 (thiamin), administer by slow iv infusion;
symptomatic care: treat convulsions conservatively: iv diazepam (Valium®), 0.5-2 mg/kg; repeat as necessary; if diazepam does not control the convulsions, iv sodium pentobarbitone, 30 mg/kg, may prove effective; care should be exercised with barbiturates due to their cardiorespiratory depressant effects;

[labinv~1.gif] Laboratory analysis
Samples of: