Rodenticide. Available in mixtures with other anticoagulant rodenticides, e.g. coumafen, difenacoum or warfarin.


[affected.gif] Animals most affected
Dogs, (other animals).


[etiology.gif] Etiology
Accidental ingestion of prepared baits (oatflakes, cereal meal or flour pastes) containing 0.1% of the active ingredient. Effective against mice.
Note: cases of iatrogenic poisoning have been reported.


[toxic.gif] Toxicity
Calcification of blood vessels and soft tissue occur as a result of increased intestinal absorption of calcium. Hypercalcaemia and hyperphosphataemia may develop; also decalcification of bones.
Oral doses in mg/kg:
LD50 rats 44
  dogs 88
  ducks 2
TD dogs 1 for7 days



[clinical.gif] Clinical features
Two or more days after ingestion, polyuropolydypsia, a syndrome, has been observed, followed by:


[lesions.gif] Lesions


[treatm~1.gif] Treatment
Treatment is of limited effect once generalized calcification has occurred. No antidote available. If mild symptoms present, the following regimen may be attempted: