Animals most affected
Ingestion of forage contaminated by industrial pollution (incidence extremely rare). Deliberate or criminal poisoning is often referred to but is rarely seen in veterinary medicine.
Cumulative poison concentrating particularly in the CNS, the skin and all structures associated with the dermis/epidermis and ectodermis. Toxic doses not well known.
0.20.5 mg/kg per day for several months
Phenomenon of pseudo-tolerance, due to 'mithridatism', or gradual reduction in intestinal absorption.
coryza, cough, laryngitis.
salivation, nausea, vomiting;
profuse watery diarrhoea or constipation.
swelling of the joints, joint pain with stiffness;
aplastic anaemia and anaemia;
Stop further exposure immediately.
dimercaprol (BAL) 2-3 mg/kg by deep im injection, every 4 hours for 3-5 days. Monitor renal function as the antidote is nephrotoxic.
hepatic protective agents.
samples of liver, kidney.