[affected.gif] Animals most affected
Cats, dogs, game animals (rabbits, hares), game birds, wild birds, poultry, pigs and wild mammals.



[etiology.gif] Etiology
Accidental ingestion of rodenticide bait



Deliberate poisoning
Poisoning with criminal intent may involve many different baits to which the anticoagulant concentrates or powders have been added. The main groups of animals targeted are dogs, occasionally cats.


Compounds
Brodifacoum, bromadiolone, chlorophacinone, coumafen, coumatetralyl, difenacoum, diphacinone.



[toxic.gif] Toxicity
Acts against vitamin K by blocking the synthesis of prothrombin, proconvertine, antihaemophilia factor B and Stuart's factor (PPSB). Toxicity varies according to the different compounds. For toxic doses, see entries for individual compounds.



[clinical.gif] Clinical features and lesions
Clinical signs of poisoning present 2-10 days post-ingestion. Haemorrhagic syndrome without specific localization.
In all animals

The site of the haemorrhaging is specific to the species of animal.

In dogs and cats

 

In pigs

 

In birds

 

In hares

 


[treatm~1.gif] Treatment

Vitamin K1

Note: the use of vitamin K3 is not reconunended as it is considerably less active and less effective than vitamin K1;

 

Symptomatic treatment

 


[labinv~1.gif] Laboratory investigations