A soil-applied, systemic carbamate insecticide and nematicide.


[affected.gif] Animals most affected
Dogs (all species).


[etiology.gif] Etiology
Accidental ingestion of microgranules containing 5% of the active compound.
Criminal poisoning of dogs is very frequent, with the microgranules being concealed in meat baits.


[toxic.gif] Toxicity
Methylcarbamate inhibits cholinesterase activity.
Oral doses in mg/kg and concentrations in mg/l:

LD50 rats 0.9-1
  ducks 4.4
  guinea pigs 1
  rabbits 1.3
  dogs 5-10
LC50 (96 h) fish 1.5-8.8




[clinical.gif] Clinical features
Similar to those observed following organophosphorous poisoning. Possibility of peracute intoxication (in dogs) with:

The following general signs have been observed:


Death may occur within several hours to several days.


[lesions.gif] Lesions
Non-specific


[treatm~1.gif] Treatment
Antidotes

Note: pralidoxime is ineffective as an antidote.

Symptomatic care
emetics, if within 2 hours of ingestion;
cardiorespiratory stimulants;
adsorbents (activated vegetable charcoal);
tranquilizers, such as diazepam (valium), l-2 mg/kg iv.

(Do not administer barbiturates or other cardiorespiratory depressants.)


[labinv~1.gif] Laboratory investigations
To confirm the presence of the compound:

Measurement of cholinesterase inhibition (essential to freeze the sample immediately as the enzymes degrade very rapidly):



[case.gif] Case summaries
Two dogs had ingested granules of aldicarb. Within a few minutes, both had hypersalivation, vomiting, severe myoclonus and cardiac arrhythmias. The dogs died 15 and 30 minutes respectively post-ingestion.
A German shepherd dog ingested a bait (meat scraps, containing a large quantity of small blue grains) which had been laid down at several places around a warehouse. The clinical features described by the owner of the dog included hypersalivation, retching and vomiting, shaking and respiratory difficulties. A clinical examination 30 minutes later by a veterinary surgeon confirmed the effects but noted that they were more intense, together with weeping eyes and convulsions. The animal died in less than one hour, in spite of treatment with atropine.