FHV-2 is a cell-associated feline herpesvirus, serologically distinct from feline herpesvirus 1. It was apparently isolated from a cat with feline urological syndrome (FUS), and it was suggested that it might be implicated in the aetiology of the syndrome. Other workers, however, have been unable to transmit FUS, and failed to isolate a similar agent. Serum antibody to the original isolate has currently been detected in 30% of cats in the USA, but not in cat sera in the UK. Antigenic and molecular studies on FHV-2 have shown it to be identical to herpesvirus 4 (BHV-4). BHV-4 has been isolated from cattle with respiratory and reproductive disease, and the European type strain of BHV-4 has been shown not to be infectious for domestic cats. The origin and significance of the American cat isolate remain unknown.
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