Antibody tests are available, but may not be particularly helpful in diagnosis of clinical disease as a positive test only indicates prior exposure, and around 40% of domestic cats are antibody positive. Paired serum samples, to demonstrate a rising titre, or IgM-specific assays may be more helpful.

Histopathological examination of tissues, including cerebrospinal fluid, and demonstration of tachyzoites may also assist in the diagnosis of clinical disease.

But, a diagnosis of toxoplasmosis is often only made at post-mortem examination, when the findings include pneumonia, hepatitis and mesenteric lymphadenopathy.

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