Chagas' disease, caused by Trypanosoma cruzi, is seen mainly in South Central America and the southern USA. Infection is by ingestion of a reservoir host (e.g. opossums, racoons, skunks) or from a reduviid vector (‘kissing bug’) bite. Clinical signs include depression, lymphadenopathy, cardiac failure and neurological disease. Diagnosis is by identification of trypanosomes in lymph node aspirates, serology or culture. No effective treatment in dogs.

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