Cryptococcosis occurs world-wide and has been reported, but is rarely diagnosed, in Britain. Cryptococcus neoformans is frequently associated with pigeon droppings. In man, infection is associated with immunosuppression and this may also be the case in the domestic cats and dogs.

Many organ systems can be involved, but the upper respiratory tract is the most common site of infection in cats, while in dogs neurological signs associated with CNS infection are most common.

Diagnosis is based on demonstration of the organism from lesions, or detection of antigen in sera.

Treatment can be attempted with ketoconazole or a combination of amphotericin B and 5-fluorocytosine, but the prognosis is always guarded.

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