This infection, caused by the soil saprophyte Blastomyces dermatitidis, is mainly seen in North America. It can cause cutaneous, pulmonary or disseminated disease.

The site and severity of the lesions determine the clinical signs seen, although around a half of all affected dogs have cutaneous (ulcerated, sometimes granulomatous, nodules) and ocular (uveitis, glaucoma, retinal detachment) signs.

Diagnosis is usually by identification of yeast-like organisms in smears or thin sections of lesions.

Treatment is with amphotericin B (0.5 mg/kg in dogs, 0.25 mg/kg in cats, IV three times per week for several weeks or until biochemical evidence of renal dysfunction) sometimes followed by ketoconazole (10 mg/kg orally twice daily for up to two months).

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