Examination of lymph nodes from CSD cases reveals focal necrosis, vascular proliferation and clumps of extracellular, pleomorphic bacilli visible only with special silver stains.

In BA, proliferation of small blood vessels with variable necrosis and neutrophil invasion is seen in skin lesions and often also in underlying bone marrow, lymph nodes and major organs such as spleen and liver.

Detection of Bartonella spp or A. felis

Both organisms can be difficult to grow, but under the appropriate conditions will grow slowly either on special bacterial media or in some cell cultures. More rapid identification of Bartonella spp can be made by use of a polymerase chain reaction on lesion material from human cases or blood of cats.

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