Both can be difficult to treat and, whatever the site of the lesion, drainage removal of pus is essential for effective antibiotic therapy.
Actinomyces spp are usually susceptible to long-term treatment with penicillins but not metronidazole.
Nocardia spp are often sensitive only to sulphonamides with or without trimethoprim potentiation.
Although antibiotic treatment is usually started before these organisms have been isolated, antibiotic sensitivity tests are recommended to ensure that optimum antibiotic is used.
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