In very young puppies include:

• anorexia;
• soft stools progressing to diarrhoea;
• painful abdomen: the puppies cry continually with paddling limb movements until they die;
• sometimes dyspnoea; vomiting or salivation.

• Most puppies less than 2-3 weeks old die within 1 or 2 days of onset of clinical signs.
• Sudden death in very young puppies may be due to CHV infection.
• ‘Fading puppy syndrome'.
• Puppies over 2 weeks old seldom become severely ill, but may develop respiratory signs.
• Occasionally vesicular lesions on male and female genitalia in adults.
• Abortion or stillborn puppies from bitches infected during pregnancy.
• Most infection of adults is subclinical.

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