B. bronchiseptica vaccination:
The vaccine currently available against B. bronchiseptica is an avirulent
strain, given intranasally.
It induces a good local IgA immune response and is reasonably effective.
The vaccine colonises the respiratory mucosa for several weeks post vaccination,
but at a much lower level than the virulent organism.
Probably because of the low level of shedding of the avirulent strain, it does
not seem to be readily transmitted to in-contact dogs and does not pose any problems.
There are few side effects after administration although some dogs may experience
transient coughing a few days later.
Puppies over 2 weeks of age may be vaccinated since there is no interference
with the vaccine by maternally derived antibody.
Complete immunity takes 5 days or more to develop after inoculation, and thus
dogs should not be exposed before this time: some partial immunity may be present
earlier than this.
Booster vaccination every 6-10 months is recommended, depending on potential
Dogs being given antibiotics should not be vaccinated.
Originally, systemic vaccination against B. bronchiseptica was not found
to be consistently satisfactory, with adverse reactions at the injection site
being common. However, subunit vaccines are now being developed.
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