Dogs are usually infected by aerosol.
Virus replicates in the tonsils and bronchial
lymph nodes leading to viraemia (in macrophages) and further replication in widespread
lymphoid tissues. Damage caused by this replication causes lymphopenia and immunosuppression.
Dogs may eliminate the virus at this stage, but if it is a very pathogenic strain,
or if the dog is not able to make a good immune response, then the virus spreads
to the epithelial surfaces of the respiratory, enteric and urogenital tracts, skin
and CNS. The relative involvement of these tissues determines the clinical signs
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