• Oronasal infection is followed by replication in tonsils and Peyer's patches, other lymphatic tissues and viraemia. Virus then replicates in vascular cells in many organs, and in hepatocytes, endothelial cells of renal glomeruli and the cornea and uvea.
• As well as acute disease, persistent infection of the kidneys and immune complex formation can lead to glomerulonephritis. Immune complexes also may cause corneal and uveal inflammation (blue eye). Persistently infected dogs may shed virus in their urine for up to 6 months.

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