- When CPV first appeared in the late 1970s, modified live or inactivated panleucopenia vaccines were used. These induced variable protection to C infection, generally of short duration, and only vaccines derived from CPV are now generally used.
- Inactivated CPV-2 vaccines provide protection from infection for up to one year.
- Live attenuated vaccines generally induce a longer lasting protection (up to two years' duration) and a more consistent response.
Note:Most live parvovirus vaccines of cats and dogs are shed in faeces. The degree of attenuation determines the extent of replication in and shedding of the vaccine virus from the host. A viraemia may be present 2 days post-vaccination in dogs, with antibodies appearing a day later.
Maternally derived antibody and CPV vaccination
- Puppies are usually vaccinated at 8 or 9 and 12 weeks old.
- Maternally derived antibody (MDA) can sometimes prevent an effective response to vaccination, but most modern live CPV vaccines overcome MDA.
- Booster vaccines should be administered yearly.
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