The severity of enteric disease caused by canine parvovirus is very variable. Many natural infections appear to be subclinical, and severe disease is difficult to reproduce experimentally. However, CPV-2 has been reported to account for between 25% and 50% of acute diarrhoea cases in dogs.

The diarrhoea results from loss of absorptive and digestive capacities but an inflammatory response may contribute a secretory component if a secondary bacterial infection occurs.

Mortality rates may be as high as 7-10% in pups but in adults they are generally less than 1%, although in an outbreak at one rescue kennel, 92% of dogs older than eight months of age were reported to die of CPV-2 enteropathy.

Clinical features include:

Clinical features reported with myocardial CPV-2 infection include:

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