Signs of congestive heart failure; such as pulmonary oedema, hepatic congestion, a dilated flaccid heart, ascites and hydrothorax may be evident. Cardiac muscle may contain pale white streaks associated with myocardial necrosis and rates.
CPV-2 infection is characterised by a non-supportive cardiomyopathy. In the early stages degeneration and loss of cardiac myocytes without an inflammatory cell infiltration is evident. By day 52 a lymphocytic infiltration and fibrosis may be present. Intranuclear inclusion bodies are frequent.
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