- Dogs of all ages and breeds appear to be susceptible to CCV infection. The natural route of infection is thought to be primarily by ingestion, although it is possible to infect dogs intranasally. After ingestion, CCV infects the mucosal epithelium overlying the upper two-thirds of small intestinal villi and, to a lesser extent, the colonic mucosa.
- Viraemia has not been demonstrated but virus has also been isolated from liver, meninges, lung and mesenteric and peripheral lymph nodes after oral inoculation. The clinical significance of such spread is not known.
- Virus is shed in faeces from day 3 to 16 post-inoculation, and virus neutralising antibodies are detectable in serum from days 7 to 10.
Pathological findings of CCV infection
Distension of intestinal loops by watery digesta and enlarged oedematous mesenteric lymph nodes.
Lesions are restricted to atrophy and fusion of intestinal villi and deepening of crypts, increased cellularity of the lamina propria and flattening of epithelial cells. Discharge of goblet cells may be evident and probably reflects partial healing after the earlier more severe damage. Histological evidence of recovery of the intestinal mucosa may be evident from day seven onwards.
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