There is no specific treatment for cowpox, so treatment usually consists of broad-spectrum antibiotics to control secondary and concurrent bacterial infection. Large lesions may be cleaned with antiseptics, and an Elizabethan collar or paw-bandaging may be necessary to prevent scratching.

Corticosteroids should be avoided as they may exacerbate the condition.

There is no vaccine available, and feline cowpox is not common enough to warrant development of one.

Control in exotic and big cats

Vaccinia virus does not grow well in cats, and when tested did not provoke an antibody response in a cheetah. Control of disease in exotic cat collections therefore relies largely on prompt diagnosis and isolation of affected individuals.

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