FELINE PANLEUCOPENIA PATHOLOGY
Changes often slight.
Dehydration a feature.
Evidence of vomiting or fetid diarrhoea.
Jejunum and ileum dilated and oedematous with petechial haemorrhages
('rose-red' appearance) on the serosal and mucosal surfaces.
Mesenteric lymph nodes may be oedematous and haemorrhagic.
Lesions usually present in jejunum and ileum; sometimes also duodenum
Mild to total destruction of epithelial lining, with dilatation
Crypts often filled with cellular debris.
In early cases, transient intranuclear inclusion bodies may be
Lymphoid tissue and bone marrow effects
In lymphoid tissues lymphocytic
depletion and reticulo-endothelial cell hyperplasia are regularly seen; mesenteric
lymph nodes, Peyer's patches and spleen are particularly affected, and in younger
animals also the thymus.
In bone marrow, there is a general depression in myeloid
activity with marked reduction in neutrophils and depletion of reticulum cell
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