Vitamin K synthesis impaired by antibiotic use
In all species bacterial flora in the intestine synthesize Vitamin K - which is essential for normal blood clotting. All orally administered antibiotic agents are reported to reduce the numbers of gut flora and so reduce the amount of Vitamin K produced. The following antibiotics in particular may depress blood concentrations of Vitamin K if they are given orally in high doses or for prolonged periods :
As a result caution is needed if you are contemplating the concurrent use of anticoagulants with these antibiotics.
Antibiotic-related Vitamin K deficiency is rarely recognized in dogs and cats. If you have experienced clotting defects in a cat or dog that has been treated with one of these antibiotics Provet would like to hear from you at email@example.com
Updated October 2013