This information is provided by Provet for educational purposes only.
You should seek the advice of your veterinarian if your pet is ill as only he or she can correctly advise on the diagnosis and recommend the treatment that is most appropriate for your pet.
Paracetamol poisoning is seen from time to time in both cats and dogs. Treatment with acetylcysteine or ascorbic acid (cats) is recommended
Poisoning with paracetamol is not uncommon because owners frequently administer drugs that they have available for themselves to their pets. An article on this has been broadcast on Provet - under the Petfacts section for pet owners.
Cats are more susceptible to paracetamol poisoning - which occurs at concentrations of only 45mg/kg body weight - because they :
In dogs much higher doses (250mg/kg body weight) are needed to induce toxicity - which results in liver and kidney failure.
Recommended treatment for paracetamol poisoning involves :
Even though paracetamol (acetaminophen) is not licensed for use in dogs it is being used increasingly off-label by the veterinary profession,. This is a matter of concern because efficacy and safety have not been demonstrated . In one study hepatotoxicity was present even at accepted "therapeutic" doses.
Updated October 2013