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HYPOTHYROIDISM IN DOGS
- SOME UNUSUAL CLINICAL CONSEQUENCES
First broadcast on www.provet.co.uk
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This information is provided by
Provet for educational purposes only.
You should seek the advice of your
veterinarian if your pet is ill as only he or she can correctly advise on the
diagnosis and recommend the treatment that is most appropriate for your pet.
Hypothyroidism is a common in dogs
and there are numerous atypical presentations of the disease which should be
sought during a clinical work-up Hypothyroidism is the
commonest endocrine disorder in dogs. (It is not reported to occur in cats -
except for congenital hypothyroidism which is extremely rare). Because of the
importance of thyroid hormone on metabolic rate, virtually all organ systems
are affected directly or indirectly by the hypothyroid state. The commonly
reported clinical signs of severe hypothyroidism are :
- Alopecia +/- pigmentation
- Lethargy
- Weight gain (NOT necessarily obesity)
- Dullness
- Dry, scaly skin
- Intolerance to cold
- Reduced fertility
- Constipation
- Decreased heart rate
Unusual signs are :
- Generalised weakness - slow stiff movements. This is most often
due atrophy of type II muscle fibres. Affected dogs have high blood
creatine kinase concentrations and bizarre high frequency discharges on
electromyographic examination.
- Neurological disorders including Central Nervous System and/or
Peripheral Nervous System signs including : circling, dragging front feet,
head tilt, impaired hearing, nystagmus. ** Feedback
Requested. These are common clinical signs, and often a specific diagnosis
is not reached. Provet would like to hear from YOU if you routinely screen
for hypothyroidism when such cases are presented. Please contact feedback@provet.co.uk
. Thank YOU
- Atherosclerosis - although common in humans this condition is
rare in dogs and cats. It is seen in dogs with hypothyroidism. As the
vessel lumen gets narrower it reduces blood blood flow to vital organs. In
theory this could predispose the animal to develop a true
"stroke". Feedback request. Provet would
like to hear from YOU if you have seen a case of atherosclerosis
with/without hypothyroidism, associated with the typical human signs of
"stroke" . Please contact feedback@provet.co.uk
Thank YOU.
- Stunted growth (cretinism) can be a sign of hypothyroidism
because thyroid hormones are essential for normal musculoskeletal
development.
- Lactation - unusual or prolonged lactation can occur in response
to high prolactin concentrations in the blood, stimulated by excess
thyrotropin-releasing hormone. Inappropriate lactation is not infrequently
seen in older bitches and may be due to hypothyroidism. Feedback
Request. Provet is conducting an on-line survey on this and would like to
hear from you if you have confirmed hypothyroidism in such cases. Send the
details to feedback@provet.co.uk
Thank YOU
- Secondary endocrinopathies including hypoadrenocorticism,
diabetes mellitus and hypoparathyroidism, hypogonadism may be concurrent
with hypothyroidism ...due to a generalised autoimmune reaction. Let
us know if you have seen a case at feedback@provet.co.uk
Thank YOU.
Clinical conditions which have been linked to hypothyroidism in the past
but which have not been confirmed by TSH stimulation tests in all cases are :
- Dilated cardiomyopathy in Doberman Pinschers (some cases confirmed)
- Horner's Syndrome (with facial paralysis) - no cases to support link
- Laryngeal paralysis (some cases confirmed)
- Megaoesophagus - no cases to support link
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