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This information is provided by
Provet for educational purposes only.
You should seek the advice of your
veterinarian if your pet is ill as only he or she can correctly advise on the
diagnosis and recommend the treatment that is most appropriate for your pet.
The liver is
responsible for the synthesis of many proteins - some of which are vital for
normal function, and some of which can be used as markers of liver disease The
main proteins synthesised by the liver are summarised here :
- Albumin - 25 % of all protein production in the liver
- a1-globulins
- High (HDL) and very high-density (VHDL) lipoproteins - including
cholesterol
- Glycoproteins
- Haptoglobulins
- Mucoproteins
- a2 - globulins
- Ceruloplasmin
- Glycoprotein
- Macroglobulin
- Plasminogen
- Prothrombin
- b-globulins
- Low (LDL) and very low-density (VLD) lipoproteins
- Transferrin
- Blood clotting factors*
- Factors I, II, V, VII, VIII, IX, and X
*Vitamin K is needed for some factors to be synthesised
Liver disease can affect the concentrations of these proteins in blood :
- Hypoalbuminaemia - due to chronic liver disease (eg obstructive
jaundice, cirrhosis, fibrosis). There is low total protein and an inverse
albumin:globulin ratio
- Hyperglobulinaemia - usually both a- and
b-globulins - compensatory rise to offset fall in albumin
Clinical signs associated with impaired protein synthesis by the liver
include :
- Coagulopathies - clotting factor deficiency
- Dissseminated Intravascular Coagulopathy (DIC) - due to thromboplastic
substances released from the liver
- Low prothrombin production - if it does not respond to parenteral
vitamin K supplementation it is due to severe hepatocellular disease
- Increased blood cholesterol concentrations - intrahepatic and
posthepatic cholestasis, or increased synthesis
- Hypoproteinaemia (less than 1gm/dl ) - with ascites, or peripheral
oedema
Last updated : January 2016
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