3.4 NEUROLOGICAL DISEASES OF OLD AGE CHRONIC 'OLD DOG' ENCEPHALITIS RETICULOSIS
Reticulosis is an uncommonly diagnosed condition of adult dogs which causes neurological signs either suggestive of a focal lesion with unilateral signs, or with multifocal signs, including hyperaesthesia. These signs are usually slowly progressive. Severe visual deficits may also be associated with reticulosis.

CSF examination may help in diagnosis though the neurological signs are usually non-specific. On histological examination the disease is charby perivascular mononuclear cell infiltration with proliferation of histiocyte and microglial cellular elements.

Three forms of the disease have been defined cytologically:


(1) granulomatous reticulosis (or granulomatous meningoencephalitis)
(2) neoplastic reticulosis and
(3) microgliomatosis.


Prednisolone at 1-2 mg/day orally has been recommended as treatfor this condition but the long-term prognosis is poor.