High concentrations of calcium in a ration
can reduce the bioavailability of other minerals such as copper, zinc and phosphorus
so excessive dietary intake should be avoided particularly in rations containing
relatively small amounts of trace elements, and in individuals with impaired gastrointestinal function
such as malabsorption.
High calcium intake can also stimulate hypercalcitoninism and suppress parathyroid
hormone activity which may be significant and complicate the clinical picture in
some cases. Excessive calcium intake should be avoided as this can encourage the
development of nephrocalcinosis and other soft tissue calcification in at-risk individuals.