These drugs inhibit DNA synthesis
Is used in the treatment of lymphoproliferative and myeloproliferative diseases, various sarcomas, and mammary, prostatic and thyroid carcinomas.
Premedication with an antihistamine is needed to prevent tachydysrhythmias, anaphylaxis and collapse.
slow i.v. injection 30 mg/m
every 3 weeks up to a maximum of 240 mg/m
slow i.v. injection 20 mg/m
every 3-6 weeks
Side effects include myelosuppression and myocardial damage leading to cardiomyopathy. it is excreted in bile and is contraindicated if hepatic insufficiency is present in the patient.