These are parasympatholytic drugs (reduce vagal tone) and are indicated for the treatment of symptomatic bradydysrhythmias. However, pacemaker implantation is the preferred approach in many cases. All will have atropine side effects, and tachyphylaxis develops to their vagolytic effect.



Preparations
Atropine
  • Atrocare injection: 600 ug/ml solution in 25 ml vials.
  • Atropine injection: 600 ug/ml solution in 25 ml vials.
  • Non-proprietary: 600 ug tablets.
Probantheline bromide
Pro-Banthine: 15 mg tablets.
Glycopyrrolate
Robinul: 200 ug/ml solution in 1 and 3 ml ampoules.


Dosage
Atropine

Dogs and cats: i/v or i/m dose at 20-40 ug/kg q6 to 8 h.

Dogs and cats: oral dose at 20-60 ug/kg tid/qid, use the minimum effective dose.

Probantheline

Dogs: 1-2 mg/kg bid/tid.

Cats: 7.Smgbid/tid.

Glycopyrrolate

Dogs and cats: i/v or i/m dose at 0.002-0.01 mg/kg i/m.



Indications

Symptomatic bradydysrhythmias, e.g. sinus bradycardia, sinus block/arrest, second AV block.



Side effects

Tachycardia, arrhythmias, gastrointestinal disturbances.


Back to menu